Our lab aims to elucidate the principles governing the unconscious brain’s ability to decipher the environment. To achieve this goal, we focus on two central unconsciousness states: natural loss of consciousness during sleep and pathologically induced altered consciousness following brain injuries. We take an interdisciplinary approach combining basic and clinical neuroscience with diverse aspects of the brain-body activity in health and disease. Ultimately, our research aims to uncover the abilities and limits of the sleeping brain, enhance the understanding of the processes promoting recovery of consciousness, and foster novel diagnostic and prognostic to improve medical care following severe brain injury.