Our lab studies the molecular and cellular mechanisms underlying age-dependent neurodegeneration. We address mechanistic questions in the interface between compromised RNA metabolism and neurodegeneration during the course of aging. We take innovative basic and translational science approaches to uncover new insights into the normal biology and degeneration of motor and cortical neurons and use those insights to develop therapeutic approaches to reverse neuronal vulnerability.

Our research goal is to advance the understanding of the mechanism leading to neurodegeneration with a focus on axonal growth, maintenance and regeneration in healthy and diseased neurons.